CAR-T cell therapy for the treatment of adult high-grade gliomas
Sangwoo Park, Marcela V. Maus, Bryan D. Choi
Abstract
Treatment for malignant primary brain tumors, including glioblastoma, remains a significant challenge despite advances in therapy. CAR-T cell immunotherapy represents a promising alternative to conventional treatments. This review discusses the landscape of clinical trials for CAR-T cell therapy targeting brain tumors, highlighting key advancements like novel target antigens and combinatorial strategies designed to address tumor heterogeneity and immunosuppression, with the goal of improving outcomes for patients with these aggressive cancers.
Topics & Concepts
ImmunotherapyImmunosuppressionMedicineGlioblastomaBrain tumorCell therapyCAR T-cell therapyClinical trialGliomaTargeted therapyChimeric antigen receptorOncologyCancer researchCellImmunologyCancerInternal medicinePathologyBiologyGeneticsCAR-T cell therapy researchNanowire Synthesis and ApplicationsAdvancements in Semiconductor Devices and Circuit Design