C–H Amination of Arenes with Hydroxylamine
Yi Yang See, Melanie S. Sanford
Abstract
-mediated reaction for the C-H amination of arenes with hydroxylamine. This reaction is applied to a variety of electron-rich (hetero)arene substrates, including a series of natural products and pharmaceuticals. It offers the advantages of mild conditions (room temperature), fast reaction rates (<30 min), compatibility with ambient moisture and air, scalability, and the use of inexpensive commercial reagents.
Topics & Concepts
ChemistryAminationHydroxylamineReagentMoistureOrganic chemistryCombinatorial chemistryCatalysisSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsPhenothiazines and Benzothiazines Synthesis and Activities