Chitosan/hydroxyapatite composite coatings on porous Ti6Al4V titanium implants: <i>in vitro</i> and <i>in vivo</i> studies
Ting Zhang, Xinwei Zhang, Mengyun Mao, Jiayi Li, Ting Wei, Hui Sun
Abstract
PURPOSE: Titanium implants are widely used in the treatment of dentition defects; however, due to problems such as osseointegration failure, peri-implant bone resorption, and peri-implant inflammation, their application is subject to certain restrictions. The surface modification of titanium implants can improve the implant success rate and meet the needs of clinical applications. The goal of this study was to evaluate the effect of the use of porous titanium with a chitosan/hydroxyapatite coating on osseointegration. METHODS: experiments were used to assess osteogenesis. RESULTS: experimental results also showed that the porous structure was beneficial, as bone tissue could grow into the pores, thereby exhibiting good osseointegration. CONCLUSIONS: . This study has meaningful implications for research into ways of improving the surface structures of implants and promoting implant osseointegration.