An ion mobility-mass spectrometry study of copper-metallothionein-2A: binding sites and stabilities of Cu-MT and mixed metal Cu–Ag and Cu–Cd complexes
Liqi Fan, David H. Russell
Abstract
Cu( i ) binds to human metallothionein MT2 to form stable Cu 6 - and Cu 10 -MT complexes that exhibit high gas-phase stabilities.
Topics & Concepts
ChemistryElectrospray ionizationMass spectrometryMetalCopperStoichiometryIonMetallothioneinMetal ions in aqueous solutionIon-mobility spectrometryCrystallographyInorganic chemistryAnalytical Chemistry (journal)Physical chemistryZincChromatographyOrganic chemistryTrace Elements in HealthMass Spectrometry Techniques and ApplicationsDrug Transport and Resistance Mechanisms