<i>N</i>-Allylation of Azoles with Hydrogen Evolution Enabled by Visible-Light Photocatalysis
Chang-Ming You, Cheng Huang, Sheng Tang, Peng Xiao, Shengchun Wang, Zhenhong Wei, Aiwen Lei, Hu Cai
Abstract
Direct N -allylation of azoles with hydrogen evolution has been achieved through the synergistic combination of organic photocatalysis and cobalt catalysis. The protocol bypasses stoichiometric oxidants and prefunctionalization of alkenes and produces hydrogen (H 2 ) as the byproduct. This transformation highlights high step- and atom-economy, high efficiency, and broad functional group tolerance for further derivatization, which opens a door for C–N bond formation that is valuable in heterocyclic chemistry.
Topics & Concepts
ChemistryPhotocatalysisCatalysisStoichiometryHydrogen bondPhotochemistryCombinatorial chemistryAtom economyCobaltHydrogen atomFunctional groupHydrogenDerivatizationGroup (periodic table)Organic chemistryMoleculePolymerHigh-performance liquid chromatographyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions