Reductive Deamination with Hydrosilanes Catalyzed by B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>
Huaquan Fang, Martin Oestreich
Abstract
is known to catalyze the dehydrogenative coupling of certain amines and hydrosilanes at elevated temperatures. At higher temperature, the dehydrogenation pathway competes with cleavage of the C-N bond and defunctionalization is obtained. This can be turned into a useful methodology for the transition-metal-free reductive deamination of a broad range of amines as well as heterocumulenes such as an isocyanate and an isothiocyanate.
Topics & Concepts
DeaminationDehydrogenationChemistryCatalysisBoraneBond cleavageMedicinal chemistryLewis acids and basesCleavage (geology)BoronTransition metalPolymer chemistryOrganic chemistryMaterials scienceEnzymeComposite materialFracture (geology)Organoboron and organosilicon chemistryCatalytic Cross-Coupling ReactionsSulfur-Based Synthesis Techniques