Substrate NOBINAc ligand affinity for Pd <sup>II</sup> -catalyzed enantioselective C–H activation over reactive β-C–H bonds in ferrocenyl amines
Devendra Parganiha, Raviraj Ananda Thorat, Ashwini Dilip Dhumale, Yagya Dutt Upadhyay, Raushan Kumar Jha, Saravanan Raju, Sangit Kumar
Abstract
an enhanced substrate ligand affinity. This approach resulted in a Pd-catalyzed enantioselective C-H activation, the first intermolecular annulation, and alkenylation of ferrocenyl amines with allenes and olefins, leading to ferrocene fused tetrahydropyridines and alkenylated ferrocenyl amines with up to 70% yields and 99 : 1 er.
Topics & Concepts
Enantioselective synthesisChemistryAllylic rearrangementSubstrate (aquarium)CatalysisLigand (biochemistry)DeaminationMedicinal chemistryStereochemistryHydrideReactive intermediateCombinatorial chemistryOrganic chemistryEnzymeMetalReceptorBiochemistryOceanographyGeologyCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis