Synthesis, biological evaluation, and docking studies of novel pyrrolo[2,3-b]pyridine derivatives as both ectonucleotide pyrophosphatase/phosphodiesterase inhibitors and antiproliferative agents
Saif Ullah, Mohammed I. El‐Gamal, Randa El‐Gamal, Julie Pelletier, Jean Sévigny, Mahmoud K. Shehata, Hanan S. Anbar, Jamshed Iqbal
Topics & Concepts
ChemistryDocking (animal)CytotoxicityIC50BiochemistryHypophosphatasiaPhosphodiesteraseLead compoundPyrophosphatasesIsozymeEnzymeSulfonylureaStereochemistryPharmacologyAlkaline phosphataseIn vitroDiabetes mellitusBiologyNursingMedicineEndocrinologyAdenosine and Purinergic SignalingBiochemical and Molecular ResearchPneumocystis jirovecii pneumonia detection and treatment