Gold(III)-P-chirogenic complex induces mitochondrial dysfunction in triple-negative breast cancer
Chibuzor Olelewe, Jong Hyun Kim, Samuel Ofori, R. Tyler Mertens, Sailajah Gukathasan, Samuel G. Awuah
Abstract
) in the nanomolar range (220-650 nM) across different TNBC cell lines. The lipophilic cationic character of AuPhos-19 facilitates interaction with mitochondrial OXPHOS. AuPhos-19 inhibits mitochondria respiration and induces significant AMPK activation. Depolarization of the mitochondria membrane, mitochondria ROS accumulation, and mitochondria DNA depletion provided further indication that AuPhos-19 perturbs mitochondria function. AuPhos-19 inhibits tumor growth in tumor-bearing mice. This study highlights the development of gold-based compounds targeting mitochondrial pathways for efficacious cancer treatment.
Topics & Concepts
Triple-negative breast cancerBreast cancerTriple negativeChemistryCancer researchCancerMedicineBiologyInternal medicineMetal complexes synthesis and propertiesLanthanide and Transition Metal ComplexesNanocluster Synthesis and Applications