Folate receptor-targeted PLGA-PEG nanoparticles for enhancing the activity of genistein in ovarian cancer
Arjun Patra, Swaha Satpathy, Pradeep Kumar Naik, Mohsin Kazi, Muhammad Delwar Hussain
Abstract
of GEN, GEN encapsulated NPs of PLGA, PLGA-PEG and PLGA-PEG-FA were 51.48, 26.70, 23.43 and 11.98 µg/ml, respectively. Folate-targeted PLGA nanoparticles could be developed for potential target-specific delivery of GEN in the treatment of ovarian cancer.
Topics & Concepts
PLGAPEG ratioFolate receptorOvarian cancerBioavailabilityChemistryIn vivoPharmacologyCancer cellCancerIn vitroBiochemistryMedicineBiologyInternal medicineFinanceEconomicsBiotechnologyPhytoestrogen effects and researchInfant Nutrition and HealthFolate and B Vitamins Research