Antileishmanial evaluation of triazole–butenolide conjugates: design, synthesis, <i>in vitro</i> screening, SAR and <i>in silico</i> ADME predictions
Alka Raj Pandey, Suriya P. Singh, Karthik Ramalingam, Kanchan Yadav, Amol Chhatrapati Bisen, Rabi Sankar Bhatta, Mrigank Srivastava, R. P. Tripathi, Neena Goyal, Koneni V. Sashidhara
Abstract
ADME parameter and pharmacokinetic studies indicated that the synthesized triazole-butenolide conjugates abide by the required criteria for the development of orally active drugs, and thus this scaffold can be used as a pharmacologically active framework that should be considered for the development of potential antileishmanial hits.
Topics & Concepts
ADMEButenolideIn silicoConjugateChemistryCombinatorial chemistryClick chemistryTriazoleIn vitroStereochemistryBiochemistryOrganic chemistryMathematicsMathematical analysisGeneResearch on Leishmaniasis StudiesTrypanosoma species research and implicationsSynthesis and biological activity