Cardiovascular risk factors during pregnancy impact the postpartum cardiac and vascular reverse remodeling
Ana Filipa Ferreira, Maria João Azevedo, Juliana Morais, Fábio Trindade, Francisca Saraiva, Sílvia O. Diaz, Inês N. Alves, Mariana Fragão-Marques, Carla Sousa, Ana Paula Machado, Adelino Leite‐Moreira, Benedita Sampaio‐Maia, Carla Ramalho, António S. Barros, Inês Falcão‐Pires
Abstract
This study describes the impact of cardiovascular risk factors (CVR) in pregnancy-induced remodeling and postpartum reverse remodeling (up to 1 yr) by applying advanced statistic methods (multivariate generalized linear mixed-effects models) to a prospective cohort of pregnant women. Aiming to extrapolate to pathological conditions, this invaluable "human model" allowed us to demonstrate that arterial hypertension is a critical CVR for worse RR and that ST2/IL33-receptors and CRP are potential biomarkers of postpartum hypertrophy reversal.