The C/D box small nucleolar RNA SNORD52 regulated by Upf1 facilitates Hepatocarcinogenesis by stabilizing CDK1
Cuicui Li, Long Wu, Pengpeng Liu, Kun Li, Zhonglin Zhang, Yueming He, Quanyan Liu, Ping Jiang, Zhiyong Yang, Zhisu Liu, Yufeng Yuan, Lei Chang
Abstract
Overall, the present study indicates that SNORD52 could be a potential biomarker for HCC. Targeting the Upf1/SNORD52/CDK1 pathway might have therapeutic potential for HCC.
Topics & Concepts
Small nucleolar RNACancer researchCarcinogenesisRNADownregulation and upregulationCyclin-dependent kinase 1BiologyMolecular biologyChemistryCell biologyLong non-coding RNACell cycleCellGeneGeneticsRNA modifications and cancerCancer-related molecular mechanisms researchRNA Research and Splicing