Impact of 16S rRNA Single Nucleotide Polymorphisms on Mycoplasma genitalium Organism Load with Doxycycline Treatment
Teck-Phui Chua, Jennifer Danielewski, Kaveesha Bodiyabadu, Catriona S. Bradshaw, Dorothy A. Machalek, Suzanne M. Garland, Erica L. Plummer, Lenka A. Vodstrcil, Gerald L. Murray
Abstract
= 0.76, 0.16, and 0.98, respectively). Using pooled published data from 28 isolates, no clear relationship between the SNPs and doxycycline MIC was identified. In conclusion, the low efficacy of doxycycline against M. genitalium does not appear to be due to variation in the 16S rRNA gene.
Topics & Concepts
Mycoplasma genitaliumDoxycyclineBiologyMicrobiology16S ribosomal RNAMycoplasmaRibosomal RNAAntibioticsVirologyGeneticsBacteriaGeneChlamydia trachomatisReproductive tract infections researchBlood groups and transfusionMicrobial infections and disease research