Short-chain fatty acids ameliorate necrotizing enterocolitis-like intestinal injury through enhancing Notch1-mediated single immunoglobulin interleukin-1-related receptor, toll-interacting protein, and A20 induction
Wei Yu, Aparna Venkatraman, Heather Menden, Maribel Martínez, Shahid Umar, Venkatesh Sampath
2022American Journal of Physiology-Gastrointestinal and Liver Physiology26 citationsDOIOpen Access PDF
Abstract
Short-chain fatty acids (SCFAs), such as propionate and butyrate, metabolites produced by symbiotic gut bacteria are known to be anti-inflammatory, but the mechanisms by which they protect against NEC are not fully understood. In this study, we reveal that SCFAs regulate intestinal inflammation by inducing the key TLR and IL1R inhibitors, SIGIRR and A20, through activation of the pluripotent transcriptional factor NOTCH1. Butyrate-mediated SIGIRR and A20 induction represses experimental NEC in the neonatal intestine.
Topics & Concepts
ButyrateNecrotizing enterocolitisPropionateInflammationBiologyImmunologyCell biologyChemistryBiochemistryMedicineInternal medicineFermentationInfant Nutrition and HealthClinical Nutrition and GastroenterologyNeonatal Respiratory Health Research