PBX3 promotes pentose phosphate pathway and colorectal cancer progression by enhancing G6PD expression
Xinxin Luo, Mankun Wei, Wenfang Li, Hezhao Zhao, Vivi Kasim, Shourong Wu
Abstract
. Collectively, these findings reveal a novel function of PBX3 as a regulator of G6PD, linking its oncogenic activity with tumor cell metabolic reprogramming, especially PPP. Furthermore, our results suggested that PBX3 is a potential target for metabolic-based anti-tumor therapeutic strategies.
Topics & Concepts
Pentose phosphate pathwayReprogrammingBiologyRegulatorCancer researchTranscription factorBiochemistryMetabolic pathwayCell biologyCellEnzymeGlycolysisGeneCancer, Hypoxia, and MetabolismEpigenetics and DNA MethylationPancreatic function and diabetes