Immunotherapy for Merkel cell carcinoma
Christina V. Angeles, Michael S. Sabel
Abstract
Merkel cell carcinoma (MCC) is an aggressive form of skin cancer which, while chemosensitive, has high rates of relapse and chemoresistance, limiting the impact of chemotherapy. An immunogenic tumor, the management of advanced MCC has changed dramatically with the introduction of checkpoint inhibitors. This review will focus on the impact of immunotherapy in unresectable and metastatic MCC, ongoing research in the adjuvant and neoadjuvant settings, and future directions of immune-based strategies for this challenging cancer.
Topics & Concepts
Merkel cell carcinomaMedicineImmunotherapyOncologyCarcinomaDermatologyMerkel cellInternal medicineCancer researchCancerPolyomavirus and related diseasesFull-Duplex Wireless CommunicationsAntenna Design and Analysis