Rational discovery of molecular glue degraders based on block chemistry
Junjie Wei, Wenjing Feng, Qingsong Chen, Qianbin Li, Zhuo Chen
Topics & Concepts
Drug discoveryComputational biologyRational designComputer scienceBlock (permutation group theory)NanotechnologyBiochemical engineeringChemistryDrug designPharmaceutical technologyGLUEData scienceClinical trialDrug developmentCombinatorial chemistryDrugTranslation (biology)DNA ligaseProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments