In Vitro Selection of Macrocyclic <scp>d</scp>/<scp>l</scp>-Hybrid Peptides against Human EGFR
Sayaka Imanishi, Takayuki Katoh, Yizhen Yin, Mituhiro Yamada, Marina Kawai, Hiroaki Suga
Abstract
members of macrocyclic d/l-hybrid peptides containing five kinds of d-amino acids and performance of the RaPID selection against human EGFR as a showcase to uncover PPI (protein-protein interaction) inhibitors.
Topics & Concepts
ChemistryAmino acidIn vitroFunction (biology)Computational biologyBiochemistrySelection (genetic algorithm)PeptideCombinatorial chemistryCell biologyBiologyComputer scienceArtificial intelligenceChemical Synthesis and AnalysisMonoclonal and Polyclonal Antibodies ResearchPeptidase Inhibition and Analysis