Transcriptomic profiles reveal differences between the right and left ventricle in normoxia and hypoxia
Matthew W. Gorr, Krishna Sriram, Amy M. Chinn, Abinaya Muthusamy, Paul A. Insel
Abstract
cells (which are predominantly macrophages and dendritic cells). Analysis of gene expression changes under hypoxic conditions identified multiple pathways that may contribute to hypoxia-induced changes in the RV, including increased expression of genes related to cell mitosis/proliferation and decreased expression of genes related to metabolic processes. Together, the findings indicate that the RV differs from the LV with respect to content of immune cells and expression of certain genes, thus suggesting the two ventricles differ in aspects of pathophysiology and in potential therapeutic targets for RV dysfunction.
Topics & Concepts
Hypoxia (environmental)TranscriptomeBiologyImmune systemGene expression profilingVentriclePulmonary hypertensionGene expressionInternal medicineGeneImmunologyMedicineGeneticsChemistryOxygenOrganic chemistryPulmonary Hypertension Research and TreatmentsCancer-related molecular mechanisms researchRNA modifications and cancer