Celastrol Regulates the Hsp90-NLRP3 Interaction to Alleviate Rheumatoid Arthritis
Junjie Yang, Biyao He, Longjiao Dang, Jiayu Liu, Guohao Liu, Yuwei Zhao, Pengfei Yu, Qiaoyun Wang, Lei Wang, Wenyu Xin
Topics & Concepts
Proinflammatory cytokineCelastrolInflammasomeChemistryIn vivoArthritisSignal transductionTumor necrosis factor alphaCell biologyReactive oxygen speciesHsp90In vitroPharmacologyInflammationImmunologyApoptosisBiochemistryReceptorBiologyHeat shock proteinGeneBiotechnologyAutoimmune and Inflammatory Disorders ResearchInflammasome and immune disordersNatural Compounds in Disease Treatment