Pharmacokinetics and Disposition of Contezolid in Humans: Resolution of a Disproportionate Human Metabolite for Clinical Development
Xiaojie Wu, Jian Meng, Yuan Hong, Dafang Zhong, Jicheng Yu, Guoying Cao, Xingdang Liu, Beining Guo, Yuancheng Chen, Yi Li, Yaoguo Shi, M. F. GORDEEV, Jufang Wu, Jing Zhang
Abstract
Contezolid (MRX-I), a novel oxazolidinone antibiotic, was recently approved for the treatment of serious Gram-positive infections. The pharmacokinetics and disposition of [ 14 C]contezolid were investigated in a single-dose human mass balance study.
Topics & Concepts
MetabolitePharmacokineticsFecesUrinePharmacologyChemistryAdverse effectOral administrationPhysiologyMedicineInternal medicineBiologyMicrobiologyAntimicrobial Resistance in StaphylococcusAntibiotics Pharmacokinetics and EfficacyAntibiotic Resistance in Bacteria