Lipid droplet targeting-guided hypoxic photodynamic therapy with curcumin analogs
Xuewei Li, Weimin Liu, Xiuli Zheng, Meiyu Jiang, Yimin Guo, Jie Sha, Jiasheng Wu, Haohui Ren, Honglei Gao, Shuai Wang, Pengfei Wang
Abstract
Two photosensitizers (CCOH and CCN) were designed and synthesized by introducing coumarin into the curcumin (CUR) structure. Compared with CUR, more reactive oxygen species (ROS) were generated by CCOH and CCN in type I and II synergy upon light irradiation. Cell experiments indicated that CCN with an excellent LD-targeting effect could be used to monitor the changes in the morphology and number of LDs in tumor cells during PDT.
Topics & Concepts
CurcuminPhotodynamic therapyReactive oxygen speciesChemistryCoumarinBiophysicsIrradiationCancer researchPharmacologyCombinatorial chemistryBiochemistryMedicineBiologyOrganic chemistryNuclear physicsPhysicsNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine ChemistryPhotodynamic Therapy Research Studies