Simple droplet microfluidics platform for drug screening on cancer spheroids
Caroline Parent, Kiran Raj M, Ya Zhou, Vivian Aubert, Didier Surdez, Olivier Delattre, Claire Wilhelm, Jean‐Louis Viovy
Abstract
) with chemotherapies in cancer cell lines as well as cells from a patient-derived-xenografts (PDX). As compared to microtiter plates methods, our system reduces the initial number of cells up to 10 times and opens new avenues towards primary tumors drug screening approaches.
Topics & Concepts
MicrofluidicsSpheroidMicrofabricationDrugNanotechnologyCytotoxicityBiomedical engineeringComputer scienceMaterials scienceChemistryIn vitroBiologyEngineeringPharmacologyMedicinePathologyFabricationBiochemistryAlternative medicineInnovative Microfluidic and Catalytic Techniques Innovation3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications