Development of phosphoinositide 3-kinase delta (PI3Kδ) inhibitors as potential anticancer agents through the generation of ligand-based pharmacophores and biological screening
Mahmoud A. Al-Sha’er, Mutasem O. Taha, Mahmoud A. Alelaimat
Topics & Concepts
PharmacophoreChemistryQuantitative structure–activity relationshipPI3K/AKT/mTOR pathwayIC50Virtual screeningLigand (biochemistry)In vitroStereochemistryCancerLung cancerComputational biologyPharmacologyBiochemistryReceptorSignal transductionBiologyMedicineOncologyGeneticsPI3K/AKT/mTOR signaling in cancerChronic Lymphocytic Leukemia ResearchMonoclonal and Polyclonal Antibodies Research