Stabilization of the Metastable α–Form of Indomethacin Induced by the Addition of 2-Hydroxypropyl-β-Cyclodextrin, Causing Supersaturation (Spring) and Its Sustaining Deployment (Parachute)
Ayako Wada-Hirai, Shota Shimizu, Risa Ichii, Chihiro Tsunoda, Ryosuke Hiroshige, Momoko Fujita, Ying-Peng Li, Yohsuke Shimada, Yuta Otsuka, Satoru Goto
Topics & Concepts
SupersaturationChemistrySolubilityDifferential scanning calorimetryMetastabilityPowder diffractionPrecipitationCyclodextrinNuclear chemistryCrystallographyChromatographyOrganic chemistryThermodynamicsMeteorologyPhysicsDrug Solubulity and Delivery SystemsCrystallization and Solubility StudiesAnalytical Chemistry and Chromatography