Structural characteristics of sulfated polysaccharides from <i>Sargassum horneri</i> and immune-enhancing activity of polysaccharides combined with lactic acid bacteria
Young-Sang Kim, Jin Hwang, Sang Gil Lee, Hee Young Jo, Myung Jin Oh, N.M. Liyanage, Jun-Geon Je, Hyun Joo An, You‐Jin Jeon
Abstract
(LAB) is not yet studied. In the present study, we attempted to characterize sulfated polysaccharides (SHCPs) in SH by MALDI-TOF/TOF mass spectrometry and evaluate their immune-enhancing effect on macrophage cells. The main residue of SHCPs in SH is 2-sulfated 1,4-linked L-fucose and this epitope combined with LAB shows immune enhancement properties through cytokine production at the cellular level and increases the population of lymphocytes and myelomonocytes in the adult zebrafish kidney. These results indicate that SHCPs, along with LAB, have potent immune-enhancing activity and may be utilized as a potential immunomodulatory ingredient.