Bacteriophage treatment of disseminated cutaneous Mycobacterium chelonae infection
Jessica S Little, Rebekah M. Dedrick, Krista G. Freeman, Madison Cristinziano, Bailey E. Smith, Constance A. Benson, Tulip A. Jhaveri, Lindsey R. Baden, Daniel A. Solomon, Graham F. Hatfull
Abstract
Mycobacterium chelonae is a rare cause of chronic disseminated cutaneous infections in immunocompromised patients. Multidrug-resistant M. chelonae infections present a challenge for treatment, and prolonged antimicrobial courses lead to significant toxicities and further antimicrobial resistance. We report a case of refractory cutaneous disseminated M. chelonae infection in a patient with seronegative arthritis on immunotherapy with tofacitinib that was treated with combination antimicrobial, surgical, and single bacteriophage therapy with excellent clinical response. The patient developed neutralizing antibodies against the bacteriophage but continues to have stable improvement of disease with negative biopsies and no evidence of bacterial resistance to the phage.