Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki, Hiroshi Suemizu
Topics & Concepts
CYP2B6Cytochrome P450MicrosomeHydroxylationHumanized mouseCYP3A4CYP3APharmacologyChemistryDrug metabolismCYP1A2BiochemistryEnzymeBiologyIn vivoBiotechnologyPharmacogenetics and Drug MetabolismEicosanoids and Hypertension PharmacologyDrug Transport and Resistance Mechanisms