Discovery of novel potent covalent inhibitor-based EGFR degrader with excellent in vivo efficacy
Shi Shi, Yu Du, Lei Huang, Jiaqi Cui, Jing Niu, Yungen Xu, Qihua Zhu
Topics & Concepts
In vivoEpidermal growth factor receptorEGFR inhibitorsChemistryProteasomePharmacologyCancer researchProteolysisProtein degradationIn vitroT790MReceptorMedicineBiologyBiochemistryGefitinibEnzymeBiotechnologyProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways