Disruption of adenosine 2A receptor improves the anti-tumor function of anti-mesothelin CAR T cells both in vitro and in vivo
Guodi Liu, Qian Zhang, Guoping Liu, Dehua Li, Linsong Zhang, Zhangjie Gu, Tian Huixin, Yong Zhang, Xiaoli Tian
Topics & Concepts
MesothelinCancer researchBiologyChimeric antigen receptorTumor microenvironmentCancer cellOvarian cancerT cellCancerImmunologyAntigenImmune systemGeneticsTumor cellsCAR-T cell therapy researchVirus-based gene therapy researchSilicon Carbide Semiconductor Technologies