Development of a DNA aptamer that binds to the complementarity-determining region of therapeutic monoclonal antibody and affinity improvement induced by pH-change for sensitive detection
Taro Saito, Yutaka Shimizu, Kaori Tsukakoshi, Koichi Abe, Jinhee Lee, Kinuko Ueno, Ryutaro Asano, Brian V. Jones, Tomohiro Yamada, Tatsuki Nakano, Jiaxing Tong, Asami Hishiki, Kodai Hara, Hiroshi Hashimoto, Koji Sode, Toshimasa Toyo’oka, Kenichiro Todoroki, Kazunori Ikebukuro
Topics & Concepts
AptamerBevacizumabMonoclonal antibodyChemistryComplementarity determining regionAntibodyPharmacokineticsMonoclonalMolecular biologyPharmacologyCombinatorial chemistryCancer researchComputational biologyBiologyImmunologyChemotherapyGeneticsAdvanced biosensing and bioanalysis techniquesMonoclonal and Polyclonal Antibodies ResearchAdvanced Biosensing Techniques and Applications