An ultrasound-controllable ROS-responsive nanoplatform for O<sub>2</sub> and NO generation to enhance sonodynamic therapy against multidrug-resistant bacterial infections
Jingyi Zhang, Lin Zhang, Yuhan Zhang, Ju Rong, Guoqing Wei
Abstract
FOT/Fe 3 O 4 @Lipo-ICG could effectively eradicate methicillin-resistant Staphylococcus aureus -induced local infection during ultrasound activation, offering a promising strategy for enhancing and synergizing SDT for eradicating MDR bacterial infections.
Topics & Concepts
Sonodynamic therapyMultiple drug resistanceIn vivoChemistryLiposomeAntimicrobialIn vitroStaphylococcus aureusReactive oxygen speciesPharmacologyAntibioticsMedicineBacteriaBiochemistryBiologyGeneticsOrganic chemistryBiotechnologyNanoplatforms for cancer theranosticsInhalation and Respiratory Drug DeliveryUltrasound and Hyperthermia Applications