Type I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8 <sup>+</sup> T cells
Christian Perez‐Shibayama, Ulrika Islander, Mechthild Lütge, Hung‐Wei Cheng, Lucas Onder, Sandra S. Ring, Angelina De Martin, Mario Novković, Julia Colston, Cristina Gil‐Cruz, Burkhard Ludewig
Abstract
T cell activation. In sum, these results unveil intricate circuits underlying type I IFN sensing in lymph node FRCs that enable protective antiviral immunity.
Topics & Concepts
Reticular cellCytotoxic T cellReticular connective tissueInterferonCD8Lymph nodeCell biologyLymphInterferon gammaChemistryImmunologyBiologyCytokineImmune systemPathologyMedicineAnatomyBiochemistryIn vitroSpleenT-cell and B-cell ImmunologyCAR-T cell therapy researchImmune Cell Function and Interaction