Arterial stiffness mediates the association between age and processing speed at low levels of microvascular function in humans across the adult lifespan
Kyndall V. Ransom, Miranda K. Traylor, Genevieve B. Batman, Madhuri S. Mulekar, Benjamin D. Hill, Amy R. Nelson, Joshua L. Keller
Abstract
Arterial stiffness partially mediates the association between age and processing speed in the presence of low microvascular function, as demarcated by maximum tissue oxygenation following ischemia. Central and peripheral pulse pressure remained associated with processing speed even after controlling for age. Our findings were derived from a sample that was determined to be cognitively healthy, which highlights the potential for these outcomes to be considered during trials aimed at the prevention of cognitive decline.
Topics & Concepts
Arterial stiffnessPulse wave velocityPeripheralMedicineCognitionInternal medicineCardiologyAssociation (psychology)Cognitive declineBlood pressurePsychologyDementiaDiseasePsychiatryPsychotherapistCardiovascular Health and Disease PreventionBlood Pressure and Hypertension StudiesOptical Imaging and Spectroscopy Techniques