Switchable Cobalt-Catalyzed α-Olefination and α-Alkylation of Nitriles with Primary Alcohols
Keshav Raj Paudel, Shi Xu, Keying Ding
Abstract
The first switchable α-olefination and α-alkylation of nitriles with primary alcohols catalyzed by a well-defined base transition-metal Co complex was presented. A broad variety of nitriles and primary alcohols are selectively and efficiently converted to the corresponding products by this method. It is noteworthy that the transformation is environmentally benign and atom efficient with H2 and H2O being the sole byproducts.
Topics & Concepts
ChemistryPrimary (astronomy)AlkylationCatalysisCobaltBase (topology)Organic chemistryCombinatorial chemistryNitrileAstronomyMathematical analysisMathematicsPhysicsAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsChemical Synthesis and Reactions