Polymyxin B-modified conjugated oligomer nanoparticle for targeted identification and enhanced photodynamic antimicrobial therapy
Qi Jiang, Xinrong Yan, Dan Jiao, Jiangyan Zhang, Yonggang Wu, Yongqiang Cheng
Abstract
We report a photosensitive polymyxin B-modified conjugated oligomer nanoparticle that integrates the targeted identification and synergistic photodynamic therapy in one treatment against resistant Gram-negative bacteria. The study expands the application of antibiotics and opens a new avenue for enhancing photodynamic antimicrobial therapy and fighting bacterial resistance.
Topics & Concepts
Photodynamic therapyPolymyxinOligomerAntimicrobialConjugated systemPolymyxin BAntibioticsPhotosensitizerBacteriaChemistryCombinatorial chemistryNanotechnologyMaterials sciencePhotochemistryBiologyBiochemistryOrganic chemistryGeneticsPolymerNanoplatforms for cancer theranosticsAntifungal resistance and susceptibilityAntibiotic Resistance in Bacteria