Saliva Sampling in Therapeutic Drug Monitoring and Physiologically Based Pharmacokinetic Modeling: Review
May Almukainzi
Abstract
Therapeutic drug monitoring investigations based on saliva samples can be utilized as an alternative to blood sampling for many advantages. Moreover, the development of physiologically based pharmacokinetic (PBPK) modeling tools can further help to estimate drug exposure from saliva. This review discusses the use of saliva samples and illustrates the applications and examples of PBPK modeling systems for estimating drug exposure from saliva.
Topics & Concepts
Physiologically based pharmacokinetic modellingSalivaPharmacokineticsDrugTherapeutic drug monitoringPharmacologySampling (signal processing)Blood samplingMedicineComputer scienceInternal medicineComputer visionFilter (signal processing)Pharmacological Effects and Toxicity StudiesPharmacogenetics and Drug MetabolismAdvancements in Transdermal Drug Delivery