Lessons of the month 1: Longitudinal extensive transverse myelitis following AstraZeneca COVID-19 vaccination
A. Notghi, Joseph Atley, Mark Silva
Abstract
Longitudinal extensive transverse myelitis (LETM) is a rare but recognised complication of vaccination. We report the case of a 58-year-old man admitted to hospital 10 days after his first AstraZeneca COVID-19 vaccination with progressive neurological symptoms and signs, and investigations and imaging consistent with LETM.This case reviews the literature and the investigative process behind excluding other diagnoses given the patient's background of pulmonary sarcoidosis. It is unique in being the first UK report of a case of LETM with a strong temporal link to COVID-19 vaccination.
Topics & Concepts
MedicineCoronavirus disease 2019 (COVID-19)Transverse myelitisSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakVaccinationVirologyInternal medicineImmunologyOutbreakMultiple sclerosisDiseaseInfectious disease (medical specialty)Multiple Sclerosis Research StudiesPeripheral Neuropathies and DisordersRheumatoid Arthritis Research and Therapies