Nanoparticle-mediated co-delivery of inflammasome inhibitors provides protection against sepsis
Dipika Nandi, Maharshi Debnath, James Forster, Ankit Pandey, Hariharan Bharadwaj, Ruchi Patel, Ashish Kulkarni
Abstract
survival rate of mice for LPS-induced septic peritonitis. Additionally, the synergistic approach illustrated a significant reduction in the expression of active caspase-1 as well as IL-1β inhibition integral components in the NLRP3 pathway. This study underscores the importance of integrating combination therapies facilitated by nanoparticle delivery to address the limitations of small molecule inflammasome inhibitors.
Topics & Concepts
InflammasomeNanoparticleNanotechnologySepsisChemistryMaterials scienceMedicineImmunologyBiochemistryReceptorInflammasome and immune disordersInflammation biomarkers and pathwaysKawasaki Disease and Coronary Complications