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Design, synthesis, and biological evaluation of novel imidazole derivatives possessing terminal sulphonamides as potential BRAFV600Einhibitors

Eslam M.H. Ali, Mohammed S. Abdel‐Maksoud, Usama M. Ammar, Karim I. Mersal, Kyung Ho Yoo, Park Jooryeong, Chang‐Hyun Oh

2020Bioorganic Chemistry35 citationsDOI

Topics & Concepts

ChemistryIC50Cancer cell linesCell cultureImidazoleMelanomaCombinatorial chemistryCancerKinaseCancer cellLead compoundStereochemistryIn vitroCancer researchBiochemistryBiologyInternal medicineMedicineGeneticsMelanoma and MAPK PathwaysComputational Drug Discovery MethodsSynthesis and biological activity
Design, synthesis, and biological evaluation of novel imidazole derivatives possessing terminal sulphonamides as potential BRAFV600Einhibitors | Litcius