Immunodominant antibody germlines in COVID-19
Emanuele Andreano, Rino Rappuoli
Abstract
The neutralizing antibody response to SARS-CoV-2 is dominated by antibodies deriving from germlines IGHV3-53/IGHV3-66, which are also associated with self-reacting antibodies. Could vaccines avoid the expansion of this immunodominant response, decrease the risk of autoimmunity, and still protect against emerging SARS-CoV-2 variants?
Topics & Concepts
VirologyAntibodyAntibody responseCoronavirus disease 2019 (COVID-19)BiologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ImmunologyNeutralizing antibodyMedicineInfectious disease (medical specialty)DiseasePathologySARS-CoV-2 and COVID-19 ResearchImmunotherapy and Immune ResponsesImmunodeficiency and Autoimmune Disorders