Loss of central mineralocorticoid or glucocorticoid receptors impacts auditory nerve processing in the cochlea
Philine Marchetta, Philipp Eckert, Robert Łukowski, Peter Ruth, Wibke Singer, Lukas Rüttiger, Marlies Knipper
Abstract
) ribbon numbers and ANF responses. In contrast, GR deletion shortened the latency and improved the synchronization to amplitude-modulated tones without affecting IHC ribbon numbers. These findings imply that stress hormone-dependent functions of central MR/GR contribute to "precognitive" sound processing in the cochlea.
Topics & Concepts
CochleaNeuroscienceGlucocorticoid receptorGlucocorticoidConditional gene knockoutAuditory cortexReceptorMineralocorticoid receptorMineralocorticoidBiologyEndocrinologyInternal medicineChemistryMedicineBiochemistryPhenotypeGeneHearing, Cochlea, Tinnitus, GeneticsHearing Loss and RehabilitationNoise Effects and Management