Endoplasmic Reticulum Stress in Chronic Obstructive Pulmonary Disease: Mechanisms and Future Perspectives
Yue Yu, Ailin Yang, Ganggang Yu, Haoyan Wang
Abstract
The endoplasmic reticulum (ER) is an integral organelle for maintaining protein homeostasis. Multiple factors can disrupt protein folding in the lumen of the ER, triggering ER stress and activating the unfolded protein response (UPR), which interrelates with various damage mechanisms, such as inflammation, apoptosis, and autophagy. Numerous studies have linked ER stress and UPR to the progression of chronic obstructive pulmonary disease (COPD). This review focuses on the mechanisms of other cellular processes triggered by UPR and summarizes drug intervention strategies targeting the UPR pathway in COPD to explore new therapeutic approaches and preventive measures for COPD.
Topics & Concepts
Endoplasmic reticulumUnfolded protein responseCOPDAutophagyInflammationPulmonary diseaseCell biologyMedicineHomeostasisProtein foldingImmunologyApoptosisBioinformaticsChemistryBiologyInternal medicineBiochemistryEndoplasmic Reticulum Stress and DiseaseAutophagy in Disease and TherapyHeme Oxygenase-1 and Carbon Monoxide