Visible-Light-Mediated Tandem Difluoromethylation/Cyclization of Alkenyl Aldehydes toward CF<sub>2</sub>H-Substituted Chroman-4-one Derivatives
Liu‐Liang Mao, An‐Xi Zhou, Xianhong Zhu, Hua‐Nan Peng, Lixia Quan, Jie‐Ping Wan, Shang‐Dong Yang
Abstract
An efficient and facile visible-light-mediated tandem difluoromethylation/cyclization of alkenyl aldehydes, with easily accessible and air-stable [Ph3PCF2H]+Br– as the difluoromethylation reagent, has been established. A range of CF2H-substituted chroman-4-one skeletons and their derivatives, such as 2,3-dihydroquinolin-4(1H)-ones, chroman, 3,4-dihydronaphthalen-1(2H)-one, 2,3-dihydrobenzofuran, and 2,3-dihydro-1H-inden-1-one, are efficiently produced in moderate to good yields with excellent chemoselectivity under mild reaction conditions.
Topics & Concepts
ChemoselectivityTandemReagentChemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisMaterials scienceComposite materialFluorine in Organic ChemistryInorganic Fluorides and Related Compounds