Dried blood spots for anti‐doping: Why just going volumetric may not be sufficient
Marc Luginbühl, Stefan Gaugler
Abstract
The perspective discusses quantitative DBS analysis for anti-doping testing in an athletic population and why only using volumetric sampling for this subgroup might not be enough. It presents examples to highlight where HCT variations occur, followed by a whole blood to plasma ratio and an HCT extraction bias discussion. Finally, options to correct for the HCT bias are presented. Marc Luginbühl and Stefan Gaugler are employees of the CAMAG foundation, which focuses on providing fully automated DBS analysis solutions.
Topics & Concepts
Perspective (graphical)Dried bloodBlood samplingDopingPopulationSampling (signal processing)Biomedical engineeringMedicineStatisticsComputer scienceMaterials scienceChromatographyChemistryInternal medicineMathematicsArtificial intelligenceTelecommunicationsOptoelectronicsDetectorEnvironmental healthBiosimilars and Bioanalytical MethodsHormonal and reproductive studiesErythropoietin and Anemia Treatment