IL-17 Cytokines and Chronic Lung Diseases
Felix Ritzmann, Lars Lunding, Robert Bals, Michael Wegmann, Christoph Beißwenger
Abstract
IL-17 cytokines are expressed by numerous cells (e.g., gamma delta (γδ) T, innate lymphoid (ILC), Th17, epithelial cells). They contribute to the elimination of bacteria through the induction of cytokines and chemokines which mediate the recruitment of inflammatory cells to the site of infection. However, IL-17-driven inflammation also likely promotes the progression of chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), lung cancer, cystic fibrosis, and asthma. In this review, we highlight the role of IL-17 cytokines in chronic lung diseases.
Topics & Concepts
COPDChemokineImmunologyLungInflammationMedicineInnate lymphoid cellLung cancerCystic fibrosisProinflammatory cytokineAsthmaCytokinePathologyInnate immune systemImmune systemInternal medicinePediatric health and respiratory diseasesAsthma and respiratory diseasesIL-33, ST2, and ILC Pathways