Electrooxidative Metal‐Free Cyclization of 4‐Arylaminocoumarins with DMF as C1‐Source
Yiyi Weng, Hantao Chen, Nanhui Li, Long Yang, Lutz Ackermann
Abstract
Abstract An environmentally‐benign electrochemical approach for the construction of quinoline derivatives employing N , N ‐dimethylformamide (DMF) as the methine source has been devised by cyclization of 4‐(phenylamino)‐ 2H ‐chromen‐2‐ones. In a user‐friendly undivided cell, 6H ‐chromeno[4,3‐ b ]quinolin‐6‐ones were obtained under chemical oxidant‐free and transition‐metal‐free conditions in 43–92% yields with high functional tolerance. magnified image
Topics & Concepts
ChemistryQuinolineDimethylformamideEnvironmentally friendlyTransition metalElectrochemistryMetalCombinatorial chemistryOrganic chemistryCatalysisPhysical chemistryElectrodeBiologySolventEcologyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques