Construction of Carbon‐Fluorine Bonds via Copper‐Catalyzed/‐Mediated Fluorination Reactions
Tao Dong, Gavin Chit Tsui
Abstract
Abstract The construction of carbon‐fluorine bonds is an important yet challenging task in organic synthesis. Transition metal‐catalyzed/‐mediated C−F bond forming processes have recently emerged as a viable strategy and provided access to value‐added monofluorinated compounds. A dramatic increase in fluorination methods using inexpensive and earth‐abundant copper can be seen in the past decade surpassing those using palladium and silver. This review discusses the recent development of Cu‐catalyzed/‐mediated formation of C(sp 2 )−F and C(sp 3 )−F bonds.
Topics & Concepts
FluorineCatalysisCopperCarbon fibersOrganic synthesisChemistryTransition metalCombinatorial chemistryOrganic chemistryMaterials scienceComposite materialComposite numberFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsCatalytic C–H Functionalization Methods