Hyper-inflammation after COVID-19 mARN vaccination: at the crossroads of multisystem inflammatory disease and adult-onset Still’s disease. Does terminology matter?
Cristian Băicuş, Caterina Delcea, Larisa Pinte, Gheorghe Andrei Dan
Abstract
As the pandemic evolves, different facets of the SARS-CoV-2 infection, as well as immunization, with varying complexity and prognostic implications are discovered. One of them is the multisystem inflammatory syndrome (MIS) Characterized by elevated ferritin levels and hyper-inflammation with vital implications, MIS was proposed as the fifth clinical entity to constitute the "hyperferritinaemic syndromes", alongside the macrophage activation syndrome (MAS), adult-onset Still's disease (AOSD), catastrophic anti-phospholipid syndrome and septic shock Although most reports were related to SARS-COV-2 infection, MIS was recently described in relation to COVID-19 vaccination as well